Prophylactic Mastectomy
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What is Prophylactic Mastectomy?Prophylactic mastectomy (also called preventive mastectomy) is the surgical removal of both breasts to help prevent breast cancer. Prophylactic mastectomy is a controversial procedure among members of the medical community. Many physicians do not believe that surgically removing a woman’s breast is appropriate unless it is performed as a treatment for breast cancer. However, based on recent scientific findings that show prophylactic mastectomy to be effective at preventing breast cancer, other physicians believe that certain individuals at especially high risk of breast cancer who are very worried about developing the disease may benefit from having prophylactic mastectomy. According to a statement from the American Cancer Society Board of Directors, "only very strong clinical and/or pathological indications warrant doing this type of ‘preventive operation.’" A woman’s decision to have prophylactic mastectomy should be made carefully with physicians and counselors and should be a decision comfortable to the woman. Women considering the procedure should discuss their decision with close family members, friends, or other women who have previously undergone prophylactic mastectomy, if possible. During a prophylactic mastectomy, the surgeon removes the entire breast, with its skin and nipple. This is called a simple or total mastectomy (see the mastectomy section for additional information). Because the operation is not being performed for cancer treatment, lymph node removal is not necessary. Prophylactic mastectomy can usually followed by immediate or delayed breast reconstruction. Who is a Candidate for Prophylactic Mastectomy?Women should be aware that prophylactic mastectomy is an irreversible procedure and the decision to have the surgery should be made very carefully. Women considering the procedure should consult several physicians (preferably breast cancer specialists) who can provide specific information on the woman’s individual risk of breast cancer. Physicians should also provide information on side effects, complications, and options for breast reconstruction (and the associated risks of reconstruction). It is also recommended that women who are considering prophylactic mastectomy discuss the procedure with a professional counselor who has experience dealing with patients who are considering this preventive option. Women who are at high risk of breast cancer who may wish to consider prophylactic mastectomy after weighing other preventive options for breast cancer include:
Also, some women who have had multiple breast biopsies revealing non-cancerous conditions, which have caused scar tissue and other complications that may make it difficult to detect breast cancer in the future, may wish to consider prophylactic mastectomy. According to a statement from the American Cancer Society Board of Directors, "only very strong clinical and/or pathological indications warrant doing this type of ‘preventive operation.’" Is Prophylactic Mastectomy Effective?Since most of the breast tissue is removed during prophylactic mastectomy, the chances that a woman will develop breast cancer are significantly reduced. A study conducted by Lynn C. Hartman, MD of the Mayo Clinic in Rochester, Minnesota and her colleagues found that prophylactic mastectomy can reduce the likelihood that a woman will develop breast cancer by at least 90%.(1) However, having a prophylactic mastectomy does not guarantee that a woman will never develop breast cancer. It is impossible for surgeons to remove every breast cell during mastectomy, and therefore, some breast tissue cells will remain. According to Dr. Hartman, if only three cells are left, cancer could develop from those three cells. In the Mayo Clinic study, three of the 214 women who had prophylactic mastectomy developed breast cancer within 14 years of having the surgery. While prophylactic mastectomy reduces the chances of developing breast cancer, some women identified to be at high-risk of breast cancer will never develop the disease, and thus, prophylactic mastectomy is not necessary for these women. However, a recent study published in the Journal of the American Medical Association found that the majority of women who opt for prophylactic mastectomy to lower their risk of breast cancer are satisfied with their decision.(2) In the study, Marlene H. Frost, RN, PhD of the Mayo Clinic and her colleagues studied 572 women with a family history of breast cancer who had prophylactic mastectomy between 1960 and 1993. The researchers found that 70% of the women were satisfied with the procedure, 11% were neutral, and 19% were dissatisfied. The majority of women also reported no change or favorable effects on their emotional stability, level of stress, self-esteem, sexual relationships, feelings of femininity, and satisfaction with their body appearance. What are Alternatives to Prophylactic Mastectomy to Help Lower Breast Cancer Risk?For women at high risk of breast cancer, there are a number of options available besides prophylactic mastectomy to reduce the chances of developing the disease.
Frequent monitoring: Many women at high risk for breast cancer are closely monitored by physicians with frequent clinical breast exams and mammograms (at an interval determined by the physician). All women should also practice monthly breast self-exams and see a physician immediately if they notice any changes or abnormalities. The earlier breast cancer is detected, the greater the chances for successful treatment and survival. Guidelines for all women: Because breast cancer affects approximately 1 in 8 women, all women should follow recommended screening guidelines to help detect breast cancer in its earliest stages, when the chances for survival are the greatest. The American Cancer Society, the American College of Radiology, the American College of Surgeons and the American Medical Association recommend the following:
Tamoxifen: In 1998, the U.S. Food and Drug Administration (FDA) approved the use of the drug tamoxifen for women who are at high risk of developing breast cancer. In a National Adjuvant Breast and Bowel Project (NSABP) study of 13,388 women at high risk of breast cancer (determined by family history, etc.), researchers found that the use of tamoxifen for a period of five years reduced the incidence of breast cancer by 49%. Most physicians who prescribe tamoxifen to help prevent breast cancer recommend that women take it for a period of five years. Tamoxifen has been shown to cause a number of side effects in some women, most commonly hot flashes, and poses a slight increase in the risk for endometrial cancer (cancer of the lining of the uterus), blood clotting, and other conditions. Click here to learn more about tamoxifen. STAR clinical trial: The NSABP is currently running its second major breast cancer prevention trial, the STAR trial. STAR (Study of Tamoxifen and Raloxifene) is designed to determine whether the drug raloxifene (brand name, Evista) is as effective as tamoxifen in preventing breast cancer. The researchers hope to recruit 22,000 post-menopausal women at high risk of breast cancer over the next few years to participate in STAR. Click here to learn more about the STAR trial. Additional Resources and References
Updated: September 12, 2007 |
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