The drug tamoxifen is approved by the U.S. Food and Drug Administration
(FDA) to help treat early and advanced stages of breast cancer
and prevent breast cancer recurrence (return). Tamoxifen is
also FDA approved to help prevent breast cancer in women at high risk of the disease.
Tamoxifen is an "anti-estrogen" and works by competing with estrogen to bind to
estrogen receptors in breast cancer cells. By blocking the actions of estrogen in the
breast tissue, tamoxifen helps slow the growth and reproduction of breast cancer cells.
While taking tamoxifen may benefit many
breast cancer patients (and women at high risk of the disease), tamoxifen has also been
shown to cause bothersome side effects in some women. In some instances, serious
complications including deep vein thrombosis, endometrial cancer, and stroke may develop
from tamoxifen use. Women should carefully discuss their specific risk factors for
cardiovascular and other diseases with their physicians and assess the benefits and risks
of taking tamoxifen for the treatment or prevention of breast cancer before beginning
treatment.
This section discusses the possible
side effects and complications from tamoxifen, and includes information on how women may
cope with a number of these side effects.
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Possible Side
Effects of Tamoxifen
Though the overall occurrence of side
effects is relatively low among women who take tamoxifen, the following side effects have
been reported. Many women only experience one or two of these side effects and some women
do not experience any. Women who are considering tamoxifen should discuss all potential
benefits and risks with their physicians prior to treatment. In many cases, the benefit of
treating or preventing breast cancer with tamoxifen outweighs the risk of these side
effects.
Hot flashes and other menopausal
symptoms: The most commonly reported side effect among women who take tamoxifen is a
higher occurrence of hot flashes (approximately 50% of women on tamoxifen experience hot
flashes when compared with a placebo, an inactive pill). Hot flashes may be accompanied by
sweating, flushing, or heart palpitations. Hot flashes occur when estrogen is blocked in
the hypothalamus, the part of the brain that controls the body’s thermostat. Some
women find that regular exercise can help reduce hot flashes. If the hot flashes are
particularly bothersome and do not respond to conservative measures such as exercise,
calcium, or other interventions, physicians may prescribe medications such as clonidine
(brand name, Duraclon) or Megace (brand name, Megestrol). Physicians may also recommend
taking 30 to 60-day "breaks" from tamoxifen to help reduce hot flashes and other
menopausal symptoms.
It is important to note that hot
flashes and other menopausal symptoms were also reported in women not taking tamoxifen
(i.e., the placebo group) in the National Adjuvant Breast and Bowel Project’s (NSABP)
first Breast Cancer Prevention Trial. In this trial, 80% of women on tamoxifen experienced
hot flashes while 68% of women who took a placebo (inactive pill) experienced hot flashes.
Therefore, these symptoms may be related to menopause itself and not tamoxifen use. It is
sometimes difficult to determine to what extent tamoxifen may contribute to these
symptoms, as many women with a diagnosis of breast cancer are approaching menopause or
they are post-menopausal.
Other reported menopausal symptoms in
addition to hot flashes include vaginal dryness, mood changes, headaches, and irregular
menstrual cycles. Women who experience vaginal dryness, irritation, or discharge are
encouraged to ask their physicians about using vaginal lubricants to help relieve these
symptoms. In some cases, vaginal discharge can be an indication of a more serious
condition, such as endometrial cancer, and may require further investigation. Vaginal
discharge was reported in 55% of women on tamoxifen in the NSABP’s Breast Cancer
Prevention Trial and in 35% of women who took a placebo (inactive pill).
Tamoxifen, by itself, does not cause
permanent premature menopause in younger women (i.e., women in their thirties). For most
young women who take tamoxifen, the ovaries continue to act normally and produce estrogen
in the same or slightly increased amounts. In fact, some studies have suggested that
tamoxifen may make pre-menopausal women more fertile. Therefore, precautions to avoid
pregnancy should be taken if using tamoxifen when sexually active. Tamoxifen should not be
taken during pregnancy.
Nausea or vomiting: Some women
who take tamoxifen may experience nausea or vomiting while on the medication. Nausea and
vomiting usually cease after the first few weeks on tamoxifen. Women who experience severe
nausea and vomiting while taking tamoxifen should talk to their physicians about ways to
relieve these symptoms.
Depression or mood changes: A
small number of women who take tamoxifen experience sharp mood swings or become severely
depressed. Since depression can come on slowly, over a period of several months, some
women do not realize that they are depressed. It also may be difficult to determine
whether tamoxifen is the source of the patient’s depression or if other stress
factors (such as coping with breast cancer and/or going through natural menopause) have
contributed to the depression. Depending on the individual situation, depression may be
treated with counseling or other medications. Some physicians will recommend taking 30 to
60-day "breaks" from tamoxifen to help relieve depression.
Weight gain: Large studies
conducted by the National Surgical Adjuvant Breast and Bowel
Project (NSABP) revealed that women who took a placebo (inactive pill) were just as
likely to gain weight as women who took tamoxifen. It is difficult to determine whether
weight gain is caused by tamoxifen or by other factors, such as prior cancer treatment
(especially certain chemotherapy regimens), changes in physical
activity, changes in eating habits due to the stress of coping with breast cancer, etc. A
few women who take tamoxifen experience weight loss.
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